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High-sensitivity Measurement of Nano Particle Size Distribution.
A powerful new tool for research and development in nanotechnology and life sciences, and for measuring fine bubbles.
- Evaluation of the dispersion and aggregation characteristics of particles is realized with a wide measurement range and in real time.
- The SALD-7500nano was developed to provide accurate and high-sensitivity measurement of low concentration or high-light absorption nano particles. It achieves sensitivity in the nano area about ten times higher as compared to conventional instruments. In addition, low concentration samples of less than 1ppm can be measured.
- Enables measurement of fine bubbles(micro bubbles from 100 nm to 60 μm) ,and allows real-time tracing of the changes in the bubble diameter.
- This system enables the evaluation of sub-visible particles included in biopharmaceuticals. Special options can be added to create an aggregation property evaluation system for biopharmaceuticals.
Wide Measurement Range : 7 nm to 800 μm
From primary particles to sub-visible particles and contaminants
- Changes in particle size across the 7 nm to 800 μm measurement range can be continuously measured using a single light source, single optical system and single measurement principle.
- Since a primary particle and an aggregate and contaminant can be measured with one system, the aggregation properties by a dispersion condition can be checked.
The evaluation of the dispersion and aggregation characteristics of the particles is realized with a wide measurement range and in real time.
1-Second Minimum Serial Measurement Time. Real time monitoring
- By incorporating a single light source, which does not require switching, and the wide-angle detection method, the measurement time can be reduced to a minimum of 1 second. In addition, the particle size distribution can be displayed in real time at 1-second intervals.
- Serial observations of the dispersion, cohesion or dissolution reaction processes are possible at 1-secondintervals, and these results can be saved. Functions for statistical processing and 3D display of the particle reaction processes offer multifaceted analyses and evaluations.
- Connecting the flow cell directly to the fine bubble generator enables in-line real-time monitoring of the changes in fine bubbles.
Measure Concentrations from 0.1 ppm to 20%
- Compared to other instruments, the SALD-7500nano permits measurements across an extremely broad concentration range of 0.1 ppm to 20%.
- The particle size of fine particles, particularly nano particles, varies with the concentration.
The dispersion and coagulation of nano particles can be observed while altering the concentration. - Accurate analysis of samples in which the particle size distribution changes with dilution is possible, as measurements can be conducted on the undiluted solution or after minimal dilution. For example, commercial hand creams, face creams, and rinses can be measured with hardly any pretreatment.
Measurement of Small Sample Amounts
- Drainage of a small quantity of a suspension liquid is adequate since the SALD-BC75 batch cell permits analysis of a volume of just 7 cm3. Most organic solvents can be used.
- A combination of the SALD-HC75 high-concentration sample measurement system with special glass slides featuring a shallow indentation permits measurement on just 15 micro liters.
Features of SALD-7500nano
Single detection face continuously captures forward- scattered light up to a 60° angle
The target particle size range is seamlessly covered using a single measurement principle, single optical system, and single light source. Additionally, because the SALD-7500nano does not incorporate multiple optical systems that create discontinuities in the data, accurate particle size distribution measurements are possible across the entire measurement range using a single standard. The application of the SLIT* optical system, based on sophisticated scattered light intensity tracing technology, smashes conventional wisdom to continuously capture forward-scattered light at up to a wide 60° angle on a single detector face. This achieves high resolution in the fine particle region.
* SLIT (Scattered Light Intensity Trace)
* SLIT (Scattered Light Intensity Trace)
High-Resolution / High-Sensitivity Wing Sensor ll
High-Resolution/High-Sensitivity Wing Sensor ll Forward diffracted/scattered light is detected by a “wing sensor ll”, a 76-element sensor developed using semiconductor manufacturing technology of the highest level. This sensor can detect greatly fluctuating small-angle forward scattering light with a high level of resolution and wide-angle scattering light of a low optical intensity with a high level of sensitivity. Also, side scattered light is detected by one sensor element and back scattered light is detected by four sensor elements. Accurately capturing light intensity distribution patterns with a total of 81 sensor elements enables the high-resolution, high-precision measurement of particle size distributions over a wide particle diameter range.
More Stable Optical System
The Omnidirectional Shock Absorption Frame (OSAF) fully isolates all elements of the optical system from shocks and vibrations. This eliminates concerns about adjusting the optical axis.
Built-in Self-Diagnostic Functions Ensure Easy Maintenance
These analyzers incorporate powerful self-diagnostic functions. The output signals sent by the sensors and detecting elements and the instrument operating status can be checked, facilitating easier maintenance. Using the Operation Log function, detailed information about, for example, the instrument usage status and contamination of the cells is included with all the measurement data, making it is possible to investigate the validity of measurement data obtained in the past.
Laser diffraction method ISO 13320 and JIS Z 8825-1 compliant
Tke SALD-7500nano complies with ISO 13320 and JIS Z 8825-1 laser diffraction and scattering standards.
Validation possible with JIS standard particles
System performances can be confirmed using a MBP1-10 standard particle specified in JIS Z8900-1. These samples have a broad particle size distribution, which is specified by the JIS standard. Using these samples allows verifying that the instrument is always accurate.
Allows verifying the validity of measurement results by referencing light intensity distribution data
Since light intensity distribution data (raw data) and measurement results (particle size distribution data) can be displayed on the same screen, measurement results can be verified while viewing both data sets. This allows users to verify whether the detection signal level (particle concentration) is appropriate, and to confirm the validity of measurement results from multiple aspects, such as in terms of the distribution width and the presence of aggregates and contaminants.
Wide application applicability
The system configuration can be optimized to address various uses, purposes, measurement objects, environments and conditions.
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